Dr. Lloyd M. Davis

Professor of Physics
Center for Laser Applications
University of Tennessee Space Institute
Tullahoma, TN 37388-9700

Phone: 931-393-7335
Fax: 931-454-2271
Email: ldavis@utsi.edu
Website
 

Education

• B.Sc. (Physics and Math): University of Auckland, New Zealand, 1978
• Ph.D. (Physics): University of Auckland, New Zealand, 1984; “Fluorescence Lifetime Measurements Using a Synchronously Pumped Dye Laser”

Professional Experience

• Aug. 2001-present Professor of Physics, University of Tennessee Space Institute
• Aug. 1995-July 2001 Associate Professor, University of Tennessee Space Institute
• May 1995-Aug. 1995 Summer Visiting Researcher, Oak Ridge National Laboratory
• Aug. 1993-July 1995 Assistant Professor (Tenure track), University of Tennessee Space Institute
• May 1993-July 1993 Summer Visiting Researcher, Los Alamos National Laboratory
• May 1991-Aug. 1991 Summer Visiting Researcher, Los Alamos National Laboratory
• May 1990-Aug. 1990 Summer Visiting Researcher, Los Alamos National Laboratory
• Mar. 1990 Visiting Researcher, Los Alamos National Laboratory
• May 1989-Aug. 1989 Summer Visiting Researcher, Los Alamos National Laboratory
• July 1987-July 1993 Research Assistant Professor, Center for Laser Applications, UTSI
• Apr. 1985-June 1987 Research Associate, Center for Laser Applications, UTSI
• Nov. 1984-Feb. 1985 Postdoctoral Research Associate, Physics Department, Auckland University

Teaching Experience

• Over 40 graduate-level courses taught in physics (and engineering science) at the University of Tennessee Space Institute, including the core 500-level Quantum Mechanics, Classical Mechanics, and Experimental Methods classes, the core 600-level Quantum Optics classes, also Modern Physics, Modern Optics, Laser Physics, Computational Physics, Biophysics, and special-topics research courses; Director for several short courses at on-campus and off-campus locations. Teaching in the last 5 years includes distance education classes Phys. 606, Non-linear Optics and Phys. 610, Quantum Optics to UTK.
• Preliminary examination contributor/grader, Physics 1996, 2000, 2004; Engineering Science, 1997, 1998.
• Authorized to teach at the 600-level in physics since 1988 and to direct physics doctoral dissertations since 1992.
• Served as major advisor for 4 Ph.D. and 7 M.S. students, assistant advisor for 4 Ph.D. and 3 M.S. students, and committee member for 10 Ph.D. and 6 M.S. students; presently the major advisor for 1 Ph.D., 2 M.S. students.

Research Interests

• Experimental physics:
  non-linear optics, quantum optics, ultrafast laser phenomena, femtosecond spectroscopy, applied optics, optical design, laser applications to chemical analysis, single-photon detectors and electronics, laser-material and laser-plasma interactions
• Interdisciplinary physics:
  single-molecule detection and spectroscopy, biophotonics, biophysics, chemical physics, biotechnology, nanotechnology, genomic technology, advanced microscopy
• Numerical physics:
  Monte Carlo simulations, cluster computing; Theoretical physics: fundamental quantum theory

External Funding

• Principal Investigator (PI) or co-PI on >20 grants and contracts, including ARO, DOE, NASA, NSF, NIH, the Whitaker Foundation, and Industry
• Current funding includes
  • “Applications of Single Molecule Detection for High-Throughput Pharmaceutical Drug Screening,” L.M. Davis, P.I.; Abbott Laboratories, Pharmaceutical Products Division, Abbott Park, Illinois
  • “Maximum-Likelihood Multi-Channel Fluorescence Microscopy,” L.M. Davis, P.I.; National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health

Recent Consulting and Invited Seminars

• Louisiana State University, Chemistry Dept.
• Vanderbilt University, Pharmacology Dept., Nashville, TN
• Abbott Laboratories, Pharmaceutical R&D, Chicago, IL
• Emory University, Physics Dept., Atlanta, GA
• National Institutes of Health, Laboratory of Chemical Physics, Bethesda, MD
• Kungliga Tekniska Högskolan [Royal Institute of Technology] KTH, Stockholm, Sweden
• LI-COR Inc., Biotechnology Division, Lincoln, NE

Professional Societies

• Optical Society of America (1985—present)
• International Society for Optical Engineering (SPIE) (1987—present)
• Biophysical Society (2001—present)
• Huntsville Electro-optics Society (HEOS) (1999—present)
• American Association for the Advancement of Science (1994)
• New Zealand Institute of Physics (1980—1985)
• Reviewer for the following:
  Analytical Chemistry, Applied Optics, Biophysical Journal, Current Pharmaceutical Biotechnology, Journal of the Optical Society of America B, Journal of Physical Chemistry, Journal of Microscopy, Optics Express, Review of Scientific Instruments; Research Corporation grants, The Royal Society of New Zealand Marsden Fund grants, Department of Defense Fellowship

Honors

• 2001 UT/ORNL Science Alliance Faculty Award
• 1995 Oak Ridge Institute for Science and Education Summer Faculty Award
• 1991 Whitaker Foundation Young Investigator Award
• 1991 R&D 100 award (for first single-molecule detection in solution)
• 1991 Associated Western Universities Summer Faculty Award
• 1990 Associated Western Universities Summer Faculty Award
• 1990 Associated Western Universities Faculty Travel Grant
• 1980 Senior Prize in Physics, University of Auckland, New Zealand
• 1979-84 New Zealand University Grants Scholarship; New Zealand Cancer Society Fellowship

Recent Publications / Presentations

(for a more comprehensive Publications list see http://ldavis.utsi.edu/papers.htm)

• “Maximum-Likelihood Multi-Dimensional Photon-Counting Microscopy,” L.M. Davis, G. Shen, D.A. Ball, J. Aiken, Y.V. White, Z. Sikorski, W.N. Robinson and D.W.  Piston, SPIE Optical Imaging 2006, Fifth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside at the National Institutes of Health,
  Bethesda,  MD, 25–27 September, 2006.
• “Accounting for Triplet and Saturation Effects in FCS Measurements,” L.M. Davis and G. Shen, Current Pharmaceutical Biotechnology 7, 287—301 (2006).
• “Nanoscale Emitters and Single-Molecule Detection in Nanochannels,” W.H. Hofmeister, L.M. Davis, J. Davidson, W.P. Kang, D. Li and J.P. Wikswo, Nanomaterials for Defense Applications 2006, Virginia Beach, VA, May 1—4 , 2006.
• “Time-Resolved Spectral Imaging at Low Signal Levels,” G. Shen and L.M. Davis, Biophysical Society annual meeting, February 18—22, 2006, Salt Lake City, UT; Biophysical Journal, Abstracts, 1414-pos (2006).
• “Dynamic Properties of Photoluminescence from Porous Silicon,” K.H. Lee, K.S. Jeon, D.A. Ball, G. Shen, and L.M. Davis, 96th Annual Meeting of the Korean Chemical Society, Wonju, Korea, Oct. 21-22, 2005.
• “Multi-Channel Imaging Capabilities at Low Signal Levels,” L.M. Davis, and G. Shen, Frontiers in Optics/Laser Science, Optical Society of America, Tucson, AZ, October 16—20, 2005.
• “Accounting for Saturation and Triplet Effects in FCS Measurements,” L.M. Davis, G. Shen, D.A. Ball, K.M. Swift and E.D. Matayoshi, 6th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine, Lihue, HI, July 22—28, 2005.
• “Monte Carlo Simulations for Single-Molecule Fluorescence Applications,” L.M. Davis, Presentation at special symposium on “15 years of Single-Molecule Detection”, Pittcon 2005, Orlando, FL, February 27—March 4, 2005.
• “Scanning fluorescence fluctuation spectroscopy for molecular brightness assays,” L.M. Davis, G. Shen and D.A. Ball, Biophysical Society annual meeting, Long Beach, CA, February 12—15, 2005.
• “Single-Molecule Detection and Imaging,” D.A. Ball, L.M. Davis, and G. Shen, Annual UT/ORNL Chemical Physics Workshop, Knoxville, TN, February 10-12, 2005.
• “Saturation effects in fluorescence correlation spectroscopy,” L.M. Davis, G. Shen, and D.A. Ball, SPIE Proceedings 5700, 128—137 (2005).
• “Confocal Fluorescence Microscopy for the Detection of Single Molecules in Biology,” G. Shen, D.A. Ball and L.M. Davis, Tennessee Mouse Genome Consortium Meeting, Fall Creek Falls, TN, November 18—20, 2004.
• “Single-Molecule Detection in Micron-sized Capillaries,” D.A. Ball, G. Shen and L.M. Davis, 71st Annual Meeting of the Southeastern Section of the American Physical Society, Oak Ridge, TN, November 11—13, 2004.
• “Photophysical and Instrumental Effects in Fluorescence Correlation Spectroscopy,” G. Shen, D.A. Ball and L.M. Davis, 71st Annual Meeting of the Southeastern Section of the American Physical Society, Oak Ridge, TN, November 11—13, 2004.
• “Improved understanding of fluorescence microscopy experiments by use of simulations,” L.M. Davis, G.Q. Shen and D.A. Ball, Focus on Microscopy 2004, Philadelphia, PA, April 4—8, 2004; http://www.focusonmicroscopy.org/.
• “Triplet state effects in the application of FCS to binding equilibria,” K.M. Swift, S. Beretta, E.D. Matayoshi, D.A. Ball, P.E. Williams and L.M. Davis, Biophysical Society annual meeting, February 14—18, 2004, Baltimore, MD.; Biophysical Journal 86, Number 1, Part 2 of 2, page 159a (2004).
• “Comparison of various data analysis methods for 2-color high-throughput drug-binding measurements,” L.M. Davis, D.A. Ball, P.E. Williams, E.D. Matayoshi and K.M. Swift, Oral presentation, 9th International Workshop on "Single Molecule Detection and Ultra Sensitive Analysis in the Life Sciences" Berlin, Germany September 24—26, 2003.
• “Data reduction methods for application of fluorescence correlation spectroscopy to pharmaceutical drug discovery,” L.M. Davis, P.E. Williams, D.A. Ball, E.D. Matayoshi, and K.M. Swift, Current Pharmaceutical Biotechnology 4, 451—462 (2003) [Invited paper in Special Edition titled The way down from single genes, and proteins to single molecules].
• “Dealing with reduced data acquisition times in fluorescence correlation spectroscopy for HTS applications,” L.M. Davis, D.A. Ball, P.E. Williams, E.D. Matayoshi, and K.M. Swift, SPIE Proceedings 4966, 117—128 (2003).
• “Fluorescence correlation spectroscopy and single-molecule detection for pharmaceutical drug discovery and high throughput screening,” L.M. Davis, D.A. Ball, P.E. Williams, K.M. Swift and E.D. Matayoshi, Oral presentation, Optical Society of America, Optics in the South East (OISE) Conference, Huntsville, Alabama, October 24—25, 2002; http://www.osa.org/meetings/topicals/OISE/program/, Biomedical Optics symposium.
• “Fluorescence Correlation Spectroscopy Data Reduction and application to peptide binding studies with Bcl-x_L,” L.M. Davis, D.A. Ball, P.E. Williams, K.M. Swift and E.D. Matayoshi, 5^th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine, Kaua’i, HI, June 25—29, 2002.
• “Single-molecule detection and applications,” L.M. Davis, University of Tennessee/Oak Ridge National Laboratory Bioinformatics Summit, Paris Landing, Tennessee, March 22—23, 2002.
• “Data reduction methods for application of FCS to High-Throughput Pharmaceutical Drug Screening,” L.M. Davis, D.A. Ball, P.E. Williams, E.D. Matayoshi and K.M. Swift, 6^th International Carl Zeiss Workshop on Fluorescence Correlation Spectroscopy & Related Methods, St. Louis, May 21—22, 2002.
• “Comparison of fluorescence correlation spectroscopy and other single-molecule data analysis methods for assay of protein-ligand interactions,” L.M. Davis, P.E. Williams, H.M. Cain, D.A. Ball, C.G. Parigger, E.D. Matayoshi and  K.M. Swift, 46-th Annual Meeting of the Biophysical Society, San Francisco, California, February 23—27, 2002; Biophysical Journal 82, 43a (2002).
• “Multiplexed analysis using time-resolved near-IR fluorescence for the detection of genomic material,” W.J. Stryjewski, S.A. Soper, S. Lassiter, and L.M. Davis, SPIE Proceedings 4626, 201—209 (2002).
• “Imaging of single-chromophore molecules in aqueous solution near a fused-silica interface,” L.M. Davis, W.C. Parker, D.A. Ball, J.G.K. Williams, G.R. Bashford, P. Sheaff, R. Eckles, D.T. Lamb, and L.R. Middendorf, SPIE Proceedings 4262, 301—311 (2001).
• “Imaging single molecules in solution near a fused-silica interface,” L.M. Davis, W.C. Parker, D.A. Ball, J.G.K. Williams, G. Bashford, D.L. Grone, R.D. Eckles and L.R. Middendorf, Biophysical Society annual meeting, February 17—21, 2001, Boston, MA; Biophysical Journal 80, 160a (2001).