Education
- University of Tennessee, Knoxville, TN. September 1982
to June 1988. Ph.D. in analytical chemistry.
- University of Tennessee, Knoxville, TN September 1979 to
August 1982. Graduated with honors. B.A. in chemistry.
- University of the South, Sewanee, TN. August 1971 to
June 1972.
Professional Experience
- University of Tennessee Space Institute. May 2008
to present. Research Associate Professor. The
responsibilities of the position include, but are not
limited to: graduate level teaching, performing research,
soliciting external funding for research projects and
directing the research efforts of graduate students.
- Johns Hopkins University Applied Physics Laboratory.
August 1998 to 2004. Senior Professional Chemist. June 2004
to May 2008. Principal Professional Chemist. May 2005 to May
2008. Section Supervisor, Applied Chemistry. The
responsibilities of the position include: supervision,
technical consultations with laboratory clients, training of
laboratory personnel, analytical methods development and
research.
- Johns Hopkins University. January 2001 to May
2008. Lecturer.
- University of Maryland Baltimore County. July
1998 to June 2003. Adjunct Associate Professor. Directed
graduate student researchers and teaching.
- University of Maryland Baltimore County. July
1992 to July 1998. Associate Professor. The responsibilities
of the position include, but are not limited to:
undergraduate and graduate level teaching, performing
research, soliciting external funding for research projects
and directing the research efforts of undergraduate and
graduate students.
- Ames Laboratory, Ames, IA. June 1990 to June
1992. Associate Chemist. The position's primary purpose was
the development of spectroscopic techniques for the
determination of Special Nuclear Materials for the Nuclear
Safeguards and Security Program. The analysis methods
developed were based on optical techniques that utilized the
selectivity afforded by extremely narrow bandwidth tunable
lasers.
- Oak Ridge National Laboratory, Oak Ridge, TN.
September 1988 to June 1990. Research Associate. The
position was to synthesize and spectroscopically investigate
complexes and compounds of the lanthanides and actinides to
understand the F block elements more fully. The methods used
included UV/VIS, FT-IR, Laser Fluorescence, X-Ray
Crystallography, and others.
- University of Tennessee, Knoxville, TN. June 1986
to August 1988. Research Associate. The position was to
develop and use free energy minimization computer algorithms
to investigate the secondary water chemistry of nuclear
power plants, under contract to the Tennessee Valley
Authority.
Courses Taught
- Electro-Analytical Chemistry, UMCP.
- Analytical Spectroscopy, UMBC.
- Special Topics in Chemistry: Introduction to Polymer
Chemistry, UMBC.
- Special Topics in Chemistry: Environmental Chemistry and
Analysis, UMBC.
- Introduction to Polymer Science, JHU.
- Biomimetics in Biomedical Engineering, JHU.
- Polymeric Materials, JHU.
Research
The techniques of molecular imprinting and sensitized lanthanide
luminescence have been combined to create the basis for a sensor
that can selectively measure a specific organophosphorous
compound. A complex of polymerizable sensitizing ligand
europium (III) and an organophosphorous compound are
copolymerized in a cross-linked polymer matrix. The best
coordinators are trifluoromethyl substituted
b-diketones.
The best polymerization mechanism is by Reversible Addition
Fragmentation Transfer polymerization. This approach is
allowing the production of soluble processable imprinted
materials. Analogous methodologies are currently being applied
to the production of sensors for the detection and determination
of drugs of abuse, explosives and meat spoilage. Drugs are
measured in an analogous manner to the nerve agents while the
explosives are being detected by the production of
charge-transfer complexes between the explosives molecules,
(acceptor) and immobilized amines (donor). Meat spoilage
sensing is obtained using luminescence from a transition metal
macrocyclic complex. The materials are also capable of
providing highly selective binding sites to other transducers
such as quartz crystal microbalance and surface plasmon
resonance sensors.
An additional thrust is to develop new solid phase extractants
for the removal of metal ions from environmental and wastewater
and to serve as the basis for selective ion sensors. Rather
than continuing to test existing extractants by an Edisonian
approach in the hope that an excellent extractant may be found,
we rely on chemical insights into what makes a good extractant.
The sources of these insights include coordination number,
coordination geometry, ionic size, ionic shape, and
thermodynamic affinity. Selectivity is obtained by providing
the polymeric extractants with cavities lined with complexing
ligands so arranged as to match the charge, coordination number,
coordination geometry, and size of the metal ion. Using the
metal ion as a template around which polymerizable monomeric
complexing ligands are polymerized produces these
cavity-containing polymers. The complexing ligands are ones
containing functional groups known to form highly stable
complexes with a specific metal ion and less stable complexes
with other cations. We have developed sequestering agents for
lead and uranium as well as electrochemical and optical sensors
based on this approach. We are now applying this experience in
selectivity toward preparing other form factors such as
imprinted ion exchange resin beads.
Publications
Southard, G. E., Van Houten, K. A., Ott. Jr., E. W. and
Murray, G. M, "Synthetic and Spectroscopic Characterization of
Molecularly Imprinted Polymer Phosphonate Sensors," in
Polymers and Materials for Anti-Terrorism and Homeland Defense,
ACS Symposium Series, Reynolds, J G. and Lawson, G. E., Eds.,
American Chemical Society, Washington, D. C., 2008.
Southard, G. E., Van Houten, K. A and Murray, G. M, "Soluble
and Processable Phosphonate Sensing Star Molecularly Imprinted
Polymers," Macromolecules, 40 (5) 1395-1400 (2007).
Southard, G. E., Ott Jr., E. W. Van Houten, K. A and Murray,
G. M, "Luminescent Sensing of Organophosphates Using Imprinted
Polymers Prepared by RAFT Polymerization," Analytica Chimica
Acta, 581 (2) 202-207 (2007).
Southard, G. E., Van Houten, K. A. and Murray, G. M., "Heck
Cross-Coupling for Synthesizing Metal Complexing Monomers,"
Synthesis, 2006 (15) 2475-2477 (2006).
Southard, G. E. and Murray, G. M., "Synthesis of Vinyl
Substituted βBeta-Diketones for Polymerizable Metal Complexes,"
Journal of Organic Chemistry, 70 (22) 9036-9039 (2005).
Bell, L. M. and Murray, G. M., "Selective Photo-reduction of
N-nitrosamines Combined with Micellar Electrokinetic
Chromatography and Laser Fluorimetric Detection," Journal of
Chromatography, B., 826, 160-168 (2005).
Owens, G. S., Southard, G. E., Van Houten, K. A. and Murray,
G. M., "Molecularly Imprinted Ion Exchange Resin for Fe3+,
Separation Science and Technology, 40, 2205-2211 (2005).
Kimaro, A, Kelly, L. A. and Murray, G. M., "Synthesis and
Characterization of Molecularly Imprinted Uranyl Ion Exchange
Resins," Separation Science and Technology, 40, 2035-2052
(2005).
Murray, G. M. and Southard G. E., “Metal Ion Selective
Molecularly Imprinted Materials,” in Molecular Imprinting:
Science and Technology, Yan, M. and Ramstrom, O., Eds.,
Marcel Dekker, 2005.
Murray, G. M. and Southard, G. E., “Optical Transduction
Schemes for Imprinted Polymer Sensors,” in Molecularly
Imprinted Materials, Kofinas, P., Roberts, M. J., Sellergren,
B. Eds., Materials Research Society Symposium Series Volume 787,
Warrendale, PA, 2004.
Boyd, J. W., Cobb, G. P., Southard, G. E. and Murray, G. M.
“Development of Molecularly Imprinted Polymer Sensors for
Chemical Warfare Agents,” JHUAPL Technical Digest, 25,
44-49 (2004).
Murray, G. M. and Southard, G. E., "Synthetic and
Spectroscopic Characterization of Molecularly Imprinted Polymer
Phosphonate Sensors," Polymer Preprints, 45(1) 535-536
(2004).
Perry, A. S. and Murray, G. M., "In-line Fiber Optic Light
Filter," Applied Spectroscopy, 57, 722-723 (2003).
Murray, G. M. and Southard, G. E., “Molecularly Imprinted
Ionomers,” in Molecularly Imprinted Materials-Sensors and
Other Devices, Shea, K. J., Yan, M., Roberts, M. J., Eds.,
Materials Research Society Symposium Series Volume 723,
Warrendale, PA, 2002.
Murray, G. M. and Southard, G. E., "Sensors for Chemical
Weapons Detection," IEEE Instrumentation and Measurement
Magazine, 5(4) 12-21 (2002).
Murray G. M. and Southard, G. E. "Molecularly Imprinted Ionomers,
M3.3" MRS Proceedings Volume 723, 2002.
Kimaro, A., Kelly, L. A. and Murray G. M., Molecularly
Imprinted Ionically Permeable Membrane for Uranyl Ion, Chemical
Communications, 1282-1283 (2001).
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